International Journal of

Pharmacy Review & Research

ABSTRACT

The medicinal plants are rich in secondary metabolites, which are potential sources of drugs and essential oils of therapeutic importance. One such plant of interest is Ocimum sanctum (Lamiaceae). Traditionally used since the times of ancient civilization in India and called as the “Queen of Herbs”. It contains 7.0% eugenol, carvacrol (3%) and eugenol-methyl ether (20%). It also contains caryophyllin, ursolic acid, rosmaric acid, thymol, methyl chavicol, citral, carvacrol, β-caryophyllene. It has been observed that eugenol and the essential oils possessed membrane stabilizing properties on synaptosomes, erythrocytes and the mast cells which account for the therapeutic potentials of Tulsi in management of neurological, inflammatory and allergic disorders. It was also pharmacologically evaluated and found to reduce raised blood sugar, cholesterol and triglyceride levels and activities of GPT, GOT, LDH and alkaline phosphatase in blood serum and thereby it is therapeutically used as cardioprotective, antidiabetic, hepatoprotective and hypolipidemic agent. There even more therapeutic uses of the holistic herb which are briefly discussed in this review.

Keywords: Ocimum sanctum, Eugenol, Cardioprotective, Antidiabetic, Holistic.

ABSTRACT

Wound is delineated as disruption of structural and physiological continuity of a living tissue. It may be produced by physical, chemical, thermal, microbial, or immunological damage to the tissue. Healing of wounds is one of the important areas of clinical medicines explained in many Ayurvedic texts. The Indian traditional system of medicine, Ayurveda is based on empirical knowledge of the observations and the experience over millennia. In different classical ayurvedic texts, more than 1200 diseases are mentioned. More than 1000 medicinal plants (89.93%); 58 minerals, metals or ores (5.24%); and 54 animal and marine products (4.86%) to heal wounds. Plants have the immense potential for the management and treatment of wounds. In most of the countries, a large number of plants are used by tribal and folklore for the treatment of wounds and burns. These natural agents induce healing and regeneration of the lost tissue by various mechanisms. These phytomedicine are not only cheap and affordable but are also safe. The presence of wide range of life-sustaining constituents in plants has urged scientists to examine these plants with a view to determine potential wound healing properties. Numerous pharmacological reports are available on number of plants employing different wound healing models and its underlying molecular mechanism for the validation of their traditional claims and development of potent, safe and effective and globally accepted herbal drugs for wounds.

Key words: Indian Medicinal Plants, Wound healing, Proliferative phase, Ayurvedic remedies.

ABSTRACT

A simple, rapid and economical spectrophotometric was developed for the estimation of zidovudine in bulk and tablet dosage forms. The results obtained were found to be good and sensitive. The method was validated and was found to be accurate, precise and sensitive. The λmax of the zidovudine was found to be at 266nm. Methanol used as a diluent. The method was found linear over the range of 5-25 μg per ml for zidovudine. The proposed method was validated as per the ICH and USP guidelines. The proposed method can be extended to different quality control labs and research and educational institutes for routine analysis of Zidovudine in bulk and dosage forms.

Key words: Estimation, UV Method, Zidovudine, Method.

ABSTRACT

Medicinal trees have been used both in the prevention and cure of various diseases of human and their pets with the advent of human civilization. Many system of therapy have been developed primarily based on plant. Plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non toxicity, stability, availability and renewability. They are extensively investigated for use in the development of solid dosage forms. Several medicinal trees and their products are still in home remedies and they represent a substantial proportion of the global drug market. These medicinal plants gain further importance in the region where modern medical health facilities are either not available or not easily accessible. Sterculia foetida L. Sterculiaceae is a tree with digitately lobed leaves, 5-7 leaflets, elliptic, margin entire, flowers in axillary panicles. The edible seeds eaten roasted or fried; seed used as adulterant for cocao; seed are also eaten as purge/dewormer; oil from seeds have uses in local culinary and traditional medicine; oil as an illuminate; fiber obtain from the bark used as cord; pulpwood; timber yields gum or glue used in bookbinding; fire wood and charcoal. In this context, the present study has shown the hidden potentiality of S. foetida, Sterculiaceae for its medicinal and economical importance.

Key words: Medicinal trees, Sterculia foetida, Sterculiaceae, Natural gum, Excipients, Medicinal and Economical importance.

ABSTRACT

Pashanbheda or stone breaker is a well known Indian drug referred to botanical name Bergenia ligulata. This plant already has been recognized for its role in dissolving kidney stone. Its pharmacological activity are antidiabetic, antipyretic, hepatoprotective, anticancer, antiprotozoal, diuretic, cardiovascular, antiscorbutic, antilithiatic, anti-inflammatory due to phytochemicals Bergenin, Pashaanolactone,β-Sitosterol, Stigmesterol, Tannic acid, Gallic acid, Parasorbic acid, Isovaleric acid, 1,8-cineole present in Pashanbheda.

Key words: Pashanbheda, Stone breaker, Bergenia ligulata, Pharmacological activity, Phytochemicals.

ABSTRACT

The present study to investigate the phytoconstituents, acute oral toxicity and hepatoprotective activity of aqueous extract of Malachra capitata (L.) (AMC) using CCl4 induced hepatotoxicity in male Wistar albino rats. The AMC at doses of 100, 200 and 400mg/kg, p.o and the standard drug Liv.52 (40mg/kg, p.o) were administered for 7 days in CCl4 intoxicated rats. The hepatoprotective activity was assessed by using various biochemical parameters like SGOT, SGPT, alkaline phosphatase (ALP) and acid phosphatase (ACP), also total bilirubin and urea. The biochemical changes and histopathological studies were observed on 4th and 8th day. AMC at tested doses significantly decrease (P<0.001) the elevated levels of the hepatic enzymes, total bilirubin and urea in a dose dependent manner after 3days whereas it’s subsequent return towards near normal after 7days indicating the recovery of hepatic cells. The AMC afforded significant protection against CCl4 induced hepatocellular injury.

Key words: Hepatotoxicity, CCl4, Hepatic Enzymes, Malachra capitata (L.), Hepatoprotective, AMC.

ABSTRACT

Literature survey reveals that few analytical methods were reported for the estimation of cinacalcet hydrochloride by LC, UV methods. Hence the present study aims in developing simple, rapid, precise and validated methods for cinacalcet hydrochloride in bulk. The methods are Colorimetric determination of Cinacalcet Hydrochloride by Visible Spectrophotometric method, Validation of Cinacalcet Hydrochloride by Visible Spectrophotometric method. The suitable solvent selected for performing estimation of Cinacalcet hydrochloride by UV spectroscopic method development and validation and fixed the λmax for the drug cinacalcet hydrochloride. The present study successfully estimated the Cinacalcet hydrochloride from the formulation and performed validation studies of the drug Cinacalcet hydrochloride.

Key words: Cinacalcet hydrochloride, UV spectroscopic method, validation studies.